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A pink-cushioned bent plywood armchair in the style of the Eames Chair, fitted with matching tires and an ottoman, would be hell on the balance but makes a clear (intended) comment about the difference between brand-name design icons and designs for assistive technologies.
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Roll.Charge.Light.Protect offers the idea of wheelchair spokes that light up (charged by the wheels, of course) for safer night wheeling. Definitely reminiscent of the many light-up gizmos commuter cyclists choose for helmet, seat, clothes and fenders.
Switched also did a post of design prototypes for gadgets for visually impaired users - interesting that all but one are for computerized readers/sensors of some kind. Designers often fall into the trap of assuming all assistive devices are extremely high-tech, expensive specialty items, and overlook the everyday technologies everyone uses - wonder what potential any of these have to be integrated into mass-market products, as current screen-readers are - on the iPad, for example..